Ivermectin Tablet 6mg

What Is Ivermectin 6 mg?

Ivermectin 6 mg is an oral anthelmintic medication used to treat parasitic infections caused by nematodes and ectoparasites. Ivermectin belongs to the avermectin class of drugs and is derived from Streptomyces avermitilis. It exerts broad-spectrum antiparasitic activity against organisms such as Strongyloides stercoralis, Onchocerca volvulus, Sarcoptes scabiei, and Loa loa. It functions by binding to glutamate-gated chloride ion channels in nerve and muscle cells of invertebrates, resulting in paralysis and death of the parasite. Ivermectin 6 mg is intended for systemic use under medical supervision.

What Is Ivermectin 6mg Used For?

Ivermectin 6 mg treats parasitic infections involving the skin, intestines, and eyes caused by helminths and ectoparasites.

Clinicians prescribe Ivermectin 6 mg to treat onchocerciasis (river blindness), strongyloidiasis, scabies, and cutaneous larva migrans. It is also indicated in the treatment of lymphatic filariasis, loiasis, ascariasis, and trichuriasis. Ivermectin exhibits both endoparasitic and ectoparasitic activity, making it effective for systemic deworming. Off-label, topical forms are used for pediculosis (head lice) and inflammatory skin disorders such as rosacea.

How Long Does It Take For Ivermectin 6 mg To Start Working?

Ivermectin 6 mg typically begins to work within 24 to 48 hours after administration.

The drug rapidly absorbs after oral intake and reaches peak plasma concentration within four hours.

Ivermectin 6 mg works by paralysing and killing parasites through selective binding to glutamate-gated chloride channels. The drug targets specific ion channels found in invertebrates but not in humans. These glutamate-gated chloride channels (GluCl) are located in the nerve and muscle cells of nematodes and arthropods. When Ivermectin binds to these channels, it causes an influx of chloride ions, leading to hyperpolarization of the cell membrane. This hyperpolarization inhibits electrical activity in the parasite’s nerve and muscle cells, resulting in flaccid paralysis of pharyngeal and somatic muscles, inhibition of feeding and reproduction, immobilization and death of the parasite.

Additionally, Ivermectin enhances the release of gamma-aminobutyric acid (GABA) at inhibitory synapses in the parasite’s central nervous system, which further suppresses neural activity. Because human GABA receptors are protected by the blood-brain barrier and the drug has low affinity for mammalian ion channels, Ivermectin shows a high safety profile in humans at therapeutic doses.

This dual action, paralysis and interference with neurotransmission, enables Ivermectin to rapidly neutralise adult worms, larvae, and microfilariae, making it effective for a range of parasitic diseases.

How Long Do The Effects Of Ivermectin 6mg Last?

The therapeutic effects of Ivermectin 6 mg can last up to one to two weeks following a single dose. Ivermectin has a half-life of approximately 18 hours, but its antiparasitic effects persist longer due to irreversible binding to parasite ion channels. Depending on the infection, a follow-up dose may be required after 7 to 14 days to eliminate remaining larvae or eggs. For chronic or high-burden infections, repeated courses are advised under physician guidance.

What Is The Recommended Dosage Of Ivermectin 6 mg?

The standard adult dosage of Ivermectin 6 mg depends on body weight and the type of parasitic infection. Physicians usually prescribe Ivermectin as a single dose calculated by body weight (approximately 0.15–0.2 mg/kg). For example, individuals weighing between 26 and 44 kg typically receive 6 mg. Repeat dosing is sometimes required, especially for scabies, filariasis, or strongyloidiasis. Always follow your healthcare provider’s instructions for dosage, timing, and follow-up evaluation to ensure effective parasite eradication.

How Should Ivermectin 6mg Be Taken For Best Results?

Take Ivermectin 6 mg orally on an empty stomach with a full glass of water for maximum absorption.

Ivermectin is best absorbed when taken without food. Swallow the tablet whole, or cut it into two parts if necessary. The drug should be taken at the same time each day if prescribed in multiple doses. Avoid altering your dose or stopping treatment without medical consultation, as incorrect use can contribute to treatment failure and parasite resistance.

What Are The Side Effects Of Ivermectin 6 mg?

Ivermectin 6 mg may cause mild to moderate side effects that usually resolve on their own.

Common side effects:

• Nausea
• Dizziness
• Stomach pain
• Fatigue
• Headache
• Joint pain
• Loss of appetite
• Swollen or tender lymph nodes

Rare but severe side effects:

• Seizures
• Difficulty breathing
• Vision changes
• Confusion or disorientation
• Skin rash or hives
• Swelling of the face, lips, or tongue
• Dark urine or signs of liver injury
• Urinary retention or incontinence

In case of allergic reaction or severe symptoms, seek immediate medical care. Overdose may result in neurotoxicity, leading to coma or death in rare cases.

What Are The Drug Interactions Of Ivermectin 6 mg?

Ivermectin 6 mg may interact with drugs that affect liver enzymes, central nervous system function, or immune status.

Always disclose all medications, supplements, and herbal products to your healthcare provider before starting Ivermectin 6 mg.

Can Ivermectin 6 mg Be Taken With Food Or Alcohol?

Ivermectin 6 mg should be taken on an empty stomach; avoid alcohol to prevent dizziness and side effects. Food may alter Ivermectin absorption, lowering its antiparasitic efficacy. Alcohol does not directly interact with the drug but may enhance its sedative effects and increase the risk of side effects like dizziness or nausea. Grapefruit juice should also be avoided, as it may interfere with Ivermectin metabolism through CYP3A4 inhibition.

How Should Ivermectin 6mg Be Stored?

Store Ivermectin 6 mg in a cool, dry place away from light and out of children’s reach.

• Store at room temperature between 15°C and 30°C (59°F to 86°F)
• Keep away from moisture and direct sunlight
• Do not store in the bathroom
• Keep in the original packaging to protect from light
• Do not use beyond the expiry date printed on the label
• Discard unused or expired medication as per local pharmaceutical waste regulations

Written & Reviewed By

Dr. William Henderson

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