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Modvigil 200 mg is a high-strength wakefulness-promoting tablet used to treat conditions like narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD). It contains 200 mg of modafinil and is manufactured by HAB Pharmaceuticals. As a generic version of Provigil, Modvigil 200 mg helps improve alertness and mental clarity during the day or night shifts. The effects usually begin within 2 to 4 hours and last for up to 12 hours, making it suitable for people with long work schedules or persistent sleepiness. Modvigil is taken orally and is intended for adults. It is also used off-label by healthy individuals to enhance concentration and reduce fatigue.
Treats
Narcolepsy, Shift Work Disorder, and Obstructive Sleep Apnea
Contains
Modafinil
Lasts
8-10 hours
Modvigil 200 mg is a prescription tablet designed to manage excessive sleepiness in people diagnosed with narcolepsy, sleep apnea, or shift work sleep disorder. It contains 200 mg of modafinil, a well-known central nervous system stimulant that enhances daytime alertness. Manufactured by HAB Pharmaceuticals, Modvigil 200 mg is a cost-effective generic version of Provigil. The tablet is taken by mouth and generally starts working within 2 to 4 hours. Its effects can last up to 10 to 12 hours, helping users remain focused and awake throughout demanding periods.
Modvigil 200 mg is also widely used off-label by students, professionals, and night-shift workers seeking improved attention, productivity, and cognitive control. Unlike traditional stimulants, Modvigil provides mental energy without the strong euphoria or crash associated with amphetamines. It is not approved for use in individuals under 17 and should be taken under medical supervision to ensure safety and proper dosing.
The active ingredient, modafinil, has been shown to offer modest cognitive enhancements in healthy users, especially in tasks related to memory and executive function. However, its primary use remains clinical. Modvigil works best as part of a structured treatment plan for sleep-related disorders and should not be used as a substitute for adequate rest.
Modvigil 200 mg is primarily used to treat narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD). In narcolepsy, individuals experience sudden and uncontrollable sleep attacks, which interfere with daily activities. Modvigil helps suppress these attacks by enhancing central nervous system activity. In cases of OSA, individuals experience disrupted nighttime breathing and fragmented sleep. For those with SWSD, such as nurses or security professionals working irregular or night shifts, Modvigil restores alertness during abnormal working hours and mitigates the fatigue that occurs when the sleep cycle is misaligned with natural circadian rhythms.
Modvigil 200 mg works by increasing extracellular dopamine levels in the brain, which helps promote wakefulness and sustained focus. Modafinil, the active ingredient, blocks dopamine transporters (DAT) and prevents dopamine reuptake into neurons. This raises dopamine concentrations in the synaptic cleft, which enhances alertness and mental performance.
Although this dopaminergic action is similar to that of amphetamines, modafinil binds to the transporter in a different way. This results in wakefulness without intense stimulation or strong risk of addiction. Modafinil does not directly affect serotonin or norepinephrine pathways but may raise their levels indirectly due to increased dopamine activity. The drug may also stimulate the orexin (hypocretin) system, which is critical for staying awake and regulating the body’s internal sleep-wake balance.
Peak plasma levels are reached within 2 to 4 hours of taking the tablet. Food may slow down absorption slightly, but it does not reduce the total amount absorbed. The half-life of modafinil is approximately 10 to 12 hours, providing long-lasting effects throughout the day. Modvigil is mostly metabolized by the liver, with less than 10% excreted unchanged through urine. Women often show higher blood concentrations of modafinil compared to men, likely due to differences in metabolism and clearance.
The effects of Modvigil 200 mg typically last between 12 and 15 hours, depending on the user’s metabolism, liver function, and individual sensitivity. The drug starts acting within two to four hours after administration, with peak efficacy seen around the third hour. While most users report sustained concentration and reduced fatigue throughout the workday, the total duration may vary. Those with slower metabolic rates, liver impairments, or higher body mass may experience a more prolonged effect. In contrast, rapid metabolizers or users who consume the drug with a high-fat meal may see a delayed or shortened response. Because of its extended duration, Modvigil 200 should be taken early in the day to avoid interference with nighttime sleep.
The recommended dose is one tablet (200 mg) taken once per day, ideally in the morning or before starting a night shift. This dosage is generally suitable for adults managing chronic sleepiness due to medical sleep disorders. Depending on the condition, the timing of the dose may vary. Refer to the table below for the preferred time of the medication as per the sleeping disorder.
Condition | When to Take Modvigil 200 mg |
---|---|
Narcolepsy | Early morning |
Obstructive Sleep Apnea | Early morning (with CPAP, if applicable) |
Shift Work Sleep Disorder | 1 hour before shift starts |
Do not take more than one tablet in 24 hours. Avoid dose doubling if a dose is missed. Consult your physician before making any changes, especially if you have liver issues, hypertension, or are on interacting medications.
Modvigil 200 mg should be taken orally with a full glass of water, once daily, preferably at the same time each day. The tablet can be taken with or without food, although consuming it with a high-fat meal may delay absorption. It is essential to swallow the tablet whole and not crush or chew it, as doing so could alter its release profile. To ensure consistent therapeutic levels and reduce the risk of insomnia, users should adhere to a strict dosing schedule and avoid taking the tablet too late in the day. Alcohol should be avoided, as it may amplify sedative effects or interfere with cognitive performance. Additionally, grapefruit juice should not be consumed during Modvigil therapy, since it can inhibit liver enzymes and affect drug metabolism.
Most users tolerate Modvigil 200 mg well, but some may experience mild or serious side effects. The severity and type of side effects depend on individual tolerance and interactions with other medications.
Common side effects include:
Rare but serious side effects include:
If you notice any severe symptoms, discontinue use and seek medical attention immediately.
Modvigil 200 mg interacts with drugs that are metabolized by liver enzymes, especially CYP3A4 and CYP2C19. These interactions may increase or decrease the effectiveness of either Modvigil or the other drug.
Drug Class | Examples | Interaction Effect |
---|---|---|
Stimulants | Amphetamine, Methylphenidate | Additive CNS stimulation |
Sedatives | Zolpidem, Triazolam | Reduced sedation, disrupted sleep |
MAO Inhibitors | Phenelzine, Isocarboxazid | Risk of hypertensive crisis |
Antifungals | Ketoconazole, Itraconazole | Increased Modvigil levels |
Antiepileptics | Phenytoin, Carbamazepine | Reduced Modvigil efficacy |
Hormonal contraceptives | Ethinyl estradiol | Reduced birth control effectiveness |
Psychotropics | Diazepam, SSRIs | Increased sedation or anxiety |
Beta-blockers | Propranolol | Unpredictable heart rate control |
Anticoagulants | Warfarin | Variable blood clotting response |
Immunosuppressants | Cyclosporine | Altered plasma levels |
Always inform your doctor about all drugs, vitamins, and herbal supplements you are using before starting Modvigil.
Follow the storage instructions listed below to ensure the maximum potency of your drug.
Published on: April 28, 2022
Last Modified on: May 28, 2025
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