Description
Erectile Dysfunction
Sildenafil
4 to 6 hours
Zydus Cadila
What Is Penegra?
Penegra 100 mg is a prescription medication that contains sildenafil citrate, a PDE5 inhibitor used to treat erectile dysfunction (ED) in men. It works by increasing blood flow to the penis during sexual stimulation. This helps men with ED achieve and maintain a firm erection.
What Is Penegra Used For?
Penegra is used to manage erectile dysfunction, a condition where a man cannot get or keep an erection firm enough for sexual activity. It is not a cure for ED but supports sexual function when arousal occurs. The drug helps improve the quality of erections during intercourse by enhancing natural physiological responses.
How Long Does It Take For Penegra To Start Working?
Penegra usually starts working within 30 to 60 minutes after oral administration, though the exact onset can vary based on individual health factors. These include metabolism, age, body weight, and whether the medication is taken on a full or empty stomach. For faster results, Penegra is best taken on an empty stomach.
The active ingredient in Penegra is sildenafil citrate, which belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. PDE5 is an enzyme found in the smooth muscle cells of the penis. Under normal conditions, sexual stimulation causes the release of nitric oxide (NO) in the corpus cavernosum. This chemical activates the enzyme guanylate cyclase, which increases the production of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels lead to the relaxation of smooth muscles and dilation of blood vessels in the penis. This process allows for increased blood flow, resulting in an erection.
Sildenafil works by selectively inhibiting PDE5, the enzyme responsible for breaking down cGMP. By blocking PDE5, Penegra prolongs the activity of cGMP and enhances the natural erectile response during sexual stimulation. However, the drug does not cause an erection without sexual arousal. Its effect is purely facilitative, supporting the body’s natural mechanisms when triggered by stimulation.
How Long Do The Effects Of Penegra 100 Last?
The effects of Penegra 100 mg typically last for 4 to 6 hours, depending on the individual’s physiology and dosage response. The medication has a half-life of about 3-4 hours, and its peak effect occurs within 1 hour of administration. However, its effectiveness requires sexual arousal. Without stimulation, no erection will occur, even when the drug is active in the bloodstream.
What Is The Recommended Dosage Of Penegra?
The standard recommended dose of Penegra is 100 mg taken once within a 24-hour period, about 30 to 60 minutes before planned sexual activity. It is important not to exceed one dose per day. Dosage adjustments should only be made under medical supervision, especially for men with underlying health conditions or those taking other medications.
How to Take Penegra 100mg Tablets for the Best Results?
For best results, swallow Penegra 100 mg whole with water about one hour before sexual activity. It can be taken with or without food, but faster effects occur on an empty stomach. Avoid consuming heavy or fatty meals before taking the tablet, as this may delay the onset of action. Do not crush, split, or chew the tablet. Always follow the dosage and instructions provided by your healthcare provider.
What Are The Side Effects Of Penegra Tablet?
Penegra may cause side effects, most of which are mild to moderate and go away with continued use. These effects occur as the body adjusts to the medication. However, some side effects may require medical attention.
Common Side Effects
- Headache
- Flushing (warmth or redness of the face)
- Nasal congestion
- Indigestion
- Dizziness
Less Common Side Effects
- Blurred vision
- Muscle pain
- Rash
- Diarrhea
- Sensitivity to light
Rare Side Effects
- Sudden hearing loss
- Priapism (painful erection lasting over 4 hours)
- Severe hypotension
- Vision loss in one or both eyes (NAION)
- Allergic reaction (swelling of the face, lips, or throat)
Seek immediate medical attention if any rare or severe symptoms occur.
What Are The Drug Interactions Of Penegra?
Penegra may interact with medications or substances that influence blood pressure, cardiovascular health, or liver enzymes. These interactions may change the drug’s effect or increase the risk of side effects. Below is a table of key interaction categories.
| Drug Category | Examples | Effect of Interaction |
|---|---|---|
| Nitrates | Nitroglycerin, Isosorbide Mononitrate | Can cause life-threatening low blood pressure |
| Alpha-blockers | Tamsulosin, Doxazosin | May lead to dizziness or fainting |
| Antifungals | Ketoconazole, Itraconazole | Increase sildenafil blood levels |
| Antibiotics | Erythromycin, Clarithromycin | Delay sildenafil metabolism, increase side effects |
| Antivirals | Ritonavir, Saquinavir | Increase duration and plasma levels of sildenafil |
| Other ED Drugs | Tadalafil, Vardenafil | Heightened risk of adverse effects |
| Recreational Nitrates | Poppers (Amyl nitrate) | May cause a dangerous drop in blood pressure |
Can I Take Penegra With Food Or Alcohol?
You can take Penegra with or without food, but fatty meals may delay its effects. For optimal results, take it on an empty stomach. Alcohol consumption may reduce its effectiveness and increase side effects like dizziness or hypotension. Limiting alcohol intake or avoiding it altogether while using Penegra is strongly advised.
How Should Penegra Be Stored?
Store Penegra correctly to maintain its effectiveness and safety.
- Keep in a cool, dry place below 30°C (86°F)
- Store away from direct sunlight
- Keep out of reach of children and pets
- Do not store in bathroom cabinets (humidity affects the medicine)
- Use only until the expiry date
- Keep in the original blister packaging
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