Malegra 50 mg

Description

What Is Malegra 50 Mg?

Malegra 50 mg is a prescription drug that contains sildenafil citrate, used to treat erectile dysfunction in men. Sildenafil citrate is a selective PDE5 inhibitor that increases blood flow to the penis during sexual stimulation. Malegra 50 mg improves the erectile response by supporting natural arousal mechanisms. This medicine does not cause an erection without sexual stimulation and is only effective when the nitric oxide (NO) pathway is activated. It is not approved for use in females or individuals under 18 years of age.

What Is Malegra 50 Mg Used For?

Malegra 50 mg is used to manage erectile dysfunction (ED) in adult men. Erectile dysfunction is defined as the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Malegra 50 mg does not cure ED but supports erectile function when sexual arousal is present. It provides temporary relief from symptoms and improves blood flow in the corpus cavernosum during stimulation.

How Long Does It Take For Malegra 50 Mg To Start Working?

Malegra 50 mg typically begins working within 30 to 60 minutes after oral intake. Sildenafil citrate, the active ingredient, enhances the nitric oxide–cGMP pathway in the corpus cavernosum. During sexual stimulation, nitric oxide (NO) is released by endothelial cells and nerve terminals. NO activates the enzyme guanylate cyclase, which increases intracellular levels of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels activate the enzyme cGMP-dependent protein kinase (PKG). PKG phosphorylates downstream targets such as myosin light chain phosphatase and inositol triphosphate receptors. This cascade decreases intracellular calcium concentrations, causing smooth muscle relaxation and vasodilation of the helicine arteries.

As a PDE5 inhibitor, sildenafil competitively binds to PDE5 enzymes and prevents the degradation of cGMP. Increased cGMP enhances vasodilation, allowing greater blood inflow into the erectile tissue. An erection occurs as a result of the increased volume and pressure within the corpora cavernosa. Sildenafil is ineffective in the absence of sexual stimulation due to the inactivity of the NO–cGMP pathway.

Sildenafil is metabolized primarily by the hepatic enzyme CYP3A4 and secondarily by CYP2C9. Its main metabolite, N-desmethyl sildenafil, contributes to about 20% of its pharmacological activity. Sildenafil absorption is delayed by high-fat meals and has reduced peak plasma concentrations under these conditions.

How Long Do The Effects Of Malegra 50 Mg Last?

The effects of Malegra 50 mg usually last between 4 to 6 hours. Sildenafil’s terminal half-life is approximately 3 to 5 hours. Peak plasma levels are typically achieved within 60 minutes. Duration varies with metabolic rate, overall health, age, and hepatic function. Although the physiological effect declines after 6 hours, sexual arousal remains necessary for the drug to act. Malegra 50 mg does not induce spontaneous erections.

What Is The Recommended Dosage Of Malegra 50 Mg?

The recommended starting dose of Malegra is 50 mg taken once per 24-hour period. It should be taken 30 to 60 minutes before planned sexual activity. The maximum dosing frequency is once daily. Dosage may be adjusted by a healthcare provider based on response and tolerability. Exceeding one dose in 24 hours increases the risk of adverse reactions. Patients with liver impairment, renal dysfunction, or cardiovascular disease should consult a physician before use.

How to Take Malegra 50 Mg 100mg Tablets for the Best Results?

Take Malegra 50 mg orally with water about 1 hour before sexual activity. The tablet can be taken with or without food, although faster onset occurs on an empty stomach. Avoid taking Malegra after a high-fat meal, which can delay absorption and reduce efficacy. Do not chew or break the tablet. For consistent results, take the medication under the same conditions each time.

What Are The Side Effects Of Malegra 50 Mg Tablet?

Malegra 50 mg may cause side effects, most of which are mild and transient.

Common Side Effects

• Headache
• Flushing (warmth or redness of the face)
• Nasal congestion
• Indigestion
• Dizziness

Less Common Side Effects

• Blurred vision
• Muscle pain
• Rash
• Diarrhea
• Sensitivity to light

Rare Side Effects

• Sudden hearing loss
• Priapism (prolonged or painful erection lasting over 4 hours)
• Severe hypotension
• Vision loss in one or both eyes (NAION)
• Allergic reaction (swelling of the face, lips, or throat)

Seek immediate medical help if any rare or severe effects occur.

What Are The Drug Interactions Of Malegra 50 Mg?

Malegra 50 mg may interact with drugs that affect blood pressure, liver enzymes, or erectile function.

Can I Take Malegra 50 Mg With Food Or Alcohol?

Malegra 50 mg can be taken with or without food, but high-fat meals may delay its onset. Taking Malegra on an empty stomach allows for faster absorption. Alcohol consumption may reduce the effectiveness of sildenafil and increase side effects like dizziness, headache, and hypotension. For best results, limit or avoid alcohol during use.

How Should Malegra 50 Mg Be Stored?

Follow the storage instructions listed below to ensure the maximum potency of your drug.

• Keep in a cool, dry place below 30°C (86°F)
• Store away from direct sunlight
• Keep out of reach of children and pets
• Do not store in bathroom cabinets (due to humidity)
• Use only until the expiry date
• Keep in the original blister packaging