What is Sildalist?
Sildalist 120 mg is a prescription ED medication that combines two proven active ingredients: Sildenafil and Tadalafil. Sildenafil 100 mg provides a fast-acting response, typically within 30 to 60 minutes, while Tadalafil 20 mg extends the duration of action up to 36 hours. Together, they work by enhancing the effects of nitric oxide during sexual stimulation, promoting vasodilation and improved blood flow to the penile tissues. This formulation is particularly useful for men seeking both rapid onset and prolonged sexual performance in a single dose.
What is Sildalist Used For?
Sildalist is used to treat erectile dysfunction (ED), a common condition in which men have trouble getting or keeping an erection firm enough for sexual intercourse.
Sildalist is not approved for treating pulmonary arterial hypertension (PAH) or benign prostatic hyperplasia (BPH). It is intended for as-needed use before anticipated sexual activity.
How Does Sildalist Work?
Sildalist enhances erectile function through the combined action of two PDE5 inhibitors, Sildenafil and Tadalafil, each targeting different aspects of erectile response. During sexual arousal, nitric oxide (NO) is released in the corpus cavernosum of the penis, stimulating the production of cyclic guanosine monophosphate (cGMP). This chemical causes the smooth muscles in the penile blood vessels to relax, allowing increased blood flow and facilitating an erection.
Sildenafil acts quickly by inhibiting the PDE5 enzyme, which breaks down cGMP. By preventing this degradation, Sildenafil allows cGMP levels to rise rapidly, leading to a firm erection within 30–60 minutes. Tadalafil, though slower in onset, maintains elevated cGMP levels over a prolonged period up to 36 hours, ensuring extended erectile readiness with subsequent sexual stimulation.
This dual mechanism offers both immediacy and endurance, making Sildalist particularly effective for men who desire spontaneity as well as sustained performance. However, sexual stimulation is still required for the medication to be effective; Sildalist does not cause automatic erections.
How Long Does Sildalist Last?
Sildalist typically begins to act within 30 to 60 minutes of ingestion and can remain effective up to 36 hours. However, the onset and duration may vary depending on various factors like food intake, metabolic rate, and overall health.
| Parameter | Details |
|---|---|
| Onset | 30 to 60 minutes after ingestion |
| Duration | Up to 36 hours |
| Influencing Factors | Details |
|---|---|
| Age & Health | Older age or certain conditions may slow effect |
| Metabolic Rate | Faster metabolism may reduce duration |
| Food Intake | High-fat meals can delay absorption |
| Other Medications | Some drugs can enhance or reduce effectiveness |
What is the Recommended Dosage of Sildalist Tablet?
The recommended dosage is one tablet taken orally with water, 30 to 60 minutes before sexual activity. Avoid consuming alcohol, grapefruit juice, or high-fat meals, as these can interfere with the medication’s action. Do not exceed one tablet within 24 hours to prevent the risk of side effects.
This high-dose dual-action medication should be used only under a doctor’s guidance, especially if you are new to ED treatments or have health conditions.
How to Take Sildalist?
Take one Sildalist tablet orally with water, about 30 to 60 minutes before planned sexual activity. It should be taken on an empty stomach or after a light meal. A heavy or fatty meal may delay absorption. Do not take more than one tablet in a 24-hour period. Avoid alcohol and grapefruit juice while using Sildalist, as they can interfere with its efficacy or increase side effects. Always follow your doctor’s instructions regarding dosage and frequency.
What Are the Side Effects of Sildalist Tablet?
Sildalist 120 mg, like all medications containing sildenafil and tadalafil, can cause side effects. Most side effects are mild and temporary, but some may require medical attention. The following symptoms are commonly reported side effects of Sildalist.
Common Side Effects:
- Headache
- Flushing
- Nasal congestion
- Indigestion
- Muscle pain
- Back pain
- Dizziness
- Visual disturbances
Serious Side Effects (Rare):
- Prolonged erection (priapism)
- Sudden hearing or vision loss
- Chest pain or irregular heartbeat
- Severe allergic reactions
Seek emergency medical attention if you experience serious side effects.
What are the Drug Interactions with Sildalist?
Sildalist 120 may interact with certain drugs and substances, which could either potentiate side effects or reduce its efficacy. Refer to the table below for drugs that can interact with Sildalist 120 mg.
| Drug Class / Substance | Interaction Type | Risk / Effect |
|---|---|---|
| Nitrates (e.g., nitroglycerin) | Contraindicated | Risk of severe hypotension |
| Alpha-blockers (e.g., tamsulosin) | Use with caution | Risk of low blood pressure |
| Other ED medications (e.g., Viagra, Cialis) | Avoid combination | No added benefit, higher side effects |
| CYP3A4 inhibitors (e.g., ritonavir, ketoconazole) | Increases drug level | May enhance side effects |
| CYP3A4 inducers (e.g., rifampin) | Reduces drug level | May reduce efficacy |
| Alcohol | Use sparingly | May cause dizziness or delayed reaction |
| Grapefruit / grapefruit juice | Avoid | Can interfere with drug metabolism |
| Blood pressure medications | Use with caution | Additive hypotensive effects |
How Should Sildalist 120 mg be Stored?
- Store at room temperature between 20°C to 25°C (68°F to 77°F).
- Keep in a dry place away from moisture and humidity.
- Protect from direct sunlight and excessive heat.
- Keep out of reach of children and pets.
- Store tablets in their original packaging until use.
- Do not use after the expiry date printed on the blister pack.
Can I Take Sildalist with Alcohol?
No, taking Sildalist with alcohol is not recommended. Alcohol can reduce the effectiveness of the medication by impairing blood flow and interfering with the drug’s absorption. It may also worsen side effects such as dizziness, flushing, and hypotension (low blood pressure). For optimal results and safety, Sildalist should be taken without alcohol.
How Does Sildalist Compare to Viagra?
Sildalist offers a broader therapeutic window than Viagra by combining fast-acting Sildenafil with long-lasting Tadalafil. Viagra contains only Sildenafil and typically lasts 4 to 6 hours. In contrast, Sildalist provides the same 100 mg dose of Sildenafil for rapid effect and adds 20 mg of Tadalafil to extend erectile responsiveness for up to 36 hours. This makes Sildalist more versatile for men who want both immediate and sustained support, while Viagra may be more suitable for men seeking short-duration, single-event relief.
| Feature | Sildalist 120 mg | Viagra |
|---|---|---|
| Composition | Sildenafil 100 mg + Tadalafil 20 mg | Sildenafil 100 mg only |
| Duration | Up to 36 hours | 4–6 hours |
| Cost | Generic & affordable | Brand-name, more expensive |
| Manufacturer | Centurion Laboratories | Pfizer |
How Does the Combination of Sildenafil and Tadalafil in Sildalist Affect Performance?
The combination of Sildenafil and Tadalafil in Sildalist enhances both the quality and duration of erectile function. Sildenafil delivers a quick response, improving erection firmness soon after administration. Tadalafil prolongs the duration of cGMP activity, which supports the ability to achieve subsequent erections with sexual arousal over the next 24 to 36 hours. This synergy improves erectile confidence and allows for more natural, flexible timing of sexual activity.
Is it Safe to Take Sildenafil and Tadalafil Together in Sildalist?
Yes, when combined in a fixed-dose tablet like Sildalist, Sildenafil and Tadalafil are considered safe under medical supervision. This formulation is specifically designed for concurrent use and has undergone safety evaluation in clinical contexts. However, combining Sildalist with any other PDE5 inhibitors or nitrate-containing medications is strictly contraindicated. Only take Sildalist as prescribed and consult a healthcare provider to ensure it is suitable for your health profile.
Is Sildalist More Effective Than Viagra or Cialis Alone?
In many cases, Sildalist may offer greater therapeutic benefits than using Viagra (Sildenafil alone) or Cialis (Tadalafil alone). This is due to its dual-action formula, which combines the rapid onset of Sildenafil with the extended duration of Tadalafil. It provides:
- Faster initial erection through Sildenafil (within 30–60 minutes)
- Longer-lasting performance through Tadalafil (up to 36 hours)
- Improved flexibility and confidence across multiple sexual encounters
Viagra offers faster onset but shorter duration, while Cialis provides longer duration but slower onset. Sildalist bridges both advantages in a single pill, making it a preferred option for men who seek both spontaneity and sustained performance.
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