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Modalert 100 mg is a prescription medication used to treat excessive daytime sleepiness caused by narcolepsy, sleep apnea, and shift work sleep disorder (SWSD). It contains 100 mg of modafinil and is manufactured by Sun Pharma. As a generic version of Provigil, Modalert 100 mg enhances alertness and mental function without the intense stimulation of traditional amphetamines. Taken by mouth, it starts acting within 2 to 4 hours and lasts for 10 to 12 hours. This makes it suitable for users needing mild but steady cognitive support throughout the day. Modalert is intended for adult use and is not approved for individuals under 17 years old. It is also used off-label to improve focus, reduce fatigue, and support daytime productivity under medical guidance.
Contains
Modafinil 100 mg
Lasts up to
15 hours
Manufactured by
Sun Pharmaceutical Industries Ltd
Modalert 100 mg is a modafinil-based wakefulness-promoting tablet manufactured by Sun Pharma and approved for treating sleep-related conditions such as narcolepsy, obstructive sleep apnea, and shift work disorder. Each tablet contains 100 mg of modafinil, which is a central nervous system stimulant and a generic version of Provigil. Modalert 100 mg supports cognitive performance and helps reduce excessive daytime sleepiness without creating a strong euphoric effect.
Modalert is taken orally and begins working within 2 to 4 hours after ingestion. Its effects last up to 12 hours, making it ideal for patients who need sustained mental clarity through work, school, or night shifts. Food may delay absorption slightly but does not affect the total effectiveness. It is not recommended for children or adolescents under 17.
Many healthy adults also use Modalert 100 mg off-label to improve focus, reaction time, and productivity. While clinical studies show only modest improvements in these areas, the low-to-moderate dose makes it a preferred option for those who want a balanced cognitive boost without excessive stimulation. Modalert 100 mg is most effective when used responsibly and under medical supervision.
Modalert 100 mg is used to manage excessive sleepiness caused by narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD). It is also prescribed off-label for fatigue-related neurological conditions and attention-related disorders. In narcolepsy, Modalert helps control sudden sleep attacks and supports daytime alertness by addressing the brain’s lack of hypocretin, a chemical crucial for staying awake. While it doesn’t cure the condition, it improves functioning and focus.
For people with obstructive sleep apnea, Modalert 100 mg is used when residual sleepiness persists despite the use of CPAP therapy. It helps patients stay awake and productive during the day. In shift work sleep disorder, Modalert improves alertness during night shifts or irregular working hours. It helps regulate sleep-wake cycles in people whose work schedules disrupt natural sleep patterns.
Doctors also use Modalert 100 mg off-label to manage fatigue in conditions like multiple sclerosis (MS), and to improve attention and alertness in people with ADHD or bipolar depression. It may also be taken by healthy users under medical guidance for enhanced productivity.
Modalert 100 mg works by increasing the availability of dopamine in the brain, which helps promote wakefulness, concentration, and motivation. Modafinil, the active ingredient, blocks dopamine transporters and prevents dopamine reabsorption into nerve cells. This increases dopamine levels in the brain’s synaptic spaces and improves alertness.
Although this action is similar to that of amphetamines, modafinil binds differently to the transporter, reducing the risk of euphoria or dependency. Modafinil does not directly target serotonin or norepinephrine transporters but may influence them indirectly through dopamine regulation. It may also stimulate the orexin (hypocretin) system, which supports the brain’s control over sleep-wake cycles.
After oral intake, Modalert 100 mg reaches peak blood levels in 2 to 3 hours. Food can slow down absorption slightly, but does not affect the total drug exposure. Around 60% of the drug binds to plasma proteins, and it is primarily metabolized in the liver. The effects last 10 to 12 hours, and less than 10% is eliminated unchanged in urine. Women may have higher blood concentrations than men due to slower metabolism and increased bioavailability.
Modalert 100 mg typically provides 10 to 12 hours of sustained mental clarity and reduced fatigue. After ingestion, peak effects are usually felt within 2 to 4 hours. The drug has a half-life of about 12 to 15 hours, which supports a gradual decline in energy rather than a sudden crash. This makes it suitable for daily use in people who need moderate yet stable cognitive support throughout the day. The smoother release profile is ideal for people who want enhanced wakefulness without overstimulation.
The usual recommended dose is one 100 mg tablet per day, taken orally. For narcolepsy and sleep apnea, the tablet is taken in the morning. For shift work sleep disorder, it should be taken about one hour before the work shift starts. It may be consumed with or without food. However, high-fat meals might delay how quickly the drug begins to work. While some patients may be prescribed a second 100 mg dose later in the day, the total daily dose should not exceed 400 mg. Dosage should always be determined by a healthcare provider based on individual needs.
Some of the common side effects of Modalert 100 mg are listed below.
Less common side effects
If the side effects persist for more than a day, call your doctor immediately.
Drug interactions can alter how a drug works or increase the risk of side effects. It is important to understand which medications your drug can interact with to minimize the risks. Talk to your doctor about your medical history. Here’s a list of drugs that interact with Modalert 100mg.
Drug Class / Substance | Examples | Interaction Type | Effect on Patient |
---|---|---|---|
Hormonal contraceptives | Birth control pills, patches, implants | CYP3A4 induction | Reduced contraceptive effectiveness; backup methods recommended |
Antidepressants | Sertraline, fluoxetine, amitriptyline | CYP inhibition/induction | Increased or decreased drug levels; risk of serotonin imbalance |
Antiepileptics | Phenytoin, carbamazepine, phenobarbital | Enzyme induction | Lower seizure control; monitoring required |
Antipsychotics / Anxiolytics | Clozapine, risperidone, lorazepam | Metabolism alteration | Reduced sedative or therapeutic effect |
Antifungals | Ketoconazole, itraconazole | Shared metabolism pathways | Potential toxicity or reduced antifungal action |
Blood thinners | Warfarin | CYP2C19 inhibition | Unpredictable INR changes; bleeding risk or clot formation |
Stimulants / Caffeine | Adderall, Ritalin, energy drinks | Synergistic stimulant effects | Anxiety, insomnia, palpitations |
Alcohol | Beer, wine, spirits | CNS unpredictability | Increased impairment; risk of mood swings, blackouts |
Over-the-counter sleep aids | Diphenhydramine, melatonin | Opposing pharmacological effects | Reduced effectiveness of both agents |
Herbal supplements | St. John’s Wort, valerian | Enzyme induction or sedation | Lower modafinil levels or increased drowsiness |
Follow the storage instructions listed below to ensure the maximum potency of your drug.
Published on: April 28, 2022
Last Modified on: May 17, 2025
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