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Vidalista 5mg is a prescription medication manufactured by Centurion Laboratories that contains 5mg of tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor. It is used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). Tadalafil increases blood flow to the penis when sexually aroused, supporting the achievement and maintenance of an erection. Often referred to as the “weekend pill,” its effects may last up to 36 hours. Each pack contains 10 tablets. Vidalista 5mg is a generic alternative to Cialis and is not intended for use in women or children.
Contains
Tadalafil
Treats
Erectile Dysfunction
Lasts
for around 36 hours
Manufactured By
Centurion Laboratories
Vidalista 5mg is an oral medication that contains the active ingredient tadalafil. Tadalafil is classified as a phosphodiesterase type 5 (PDE5) inhibitor. Vidalista 5mg is prescribed primarily for the treatment of erectile dysfunction (ED). It functions by enhancing blood flow to the corpus cavernosum of the penis during sexual stimulation. This vasodilatory effect helps men with ED to achieve and maintain a firm erection. It is not intended for use in individuals without ED or in women or children.
Vidalista 5mg is used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Erectile dysfunction is the inability to achieve or sustain an erection sufficient for satisfactory sexual performance. Tadalafil, the active ingredient in Vidalista 5mg, does not cure ED but helps manage it during sexual stimulation. In the United States, tadalafil is FDA-approved under the brand name Cialis to treat both ED and the signs and symptoms of BPH. Additionally, tadalafil is approved as Adcirca to improve exercise capacity in patients with pulmonary arterial hypertension (PAH).
For benign prostatic hyperplasia, tadalafil helps relieve lower urinary tract symptoms such as urinary urgency, weak stream, and nocturia. Studies show its efficacy is comparable to alpha-blockers like tamsulosin, with a favorable safety profile. For PAH, tadalafil works by dilating pulmonary vessels, which reduces pulmonary arterial pressure and enhances physical endurance.
Vidalista 5mg typically begins to work within 30 to 60 minutes after oral administration. The onset time can vary depending on the patient’s metabolic rate, food intake, and general health.
Tadalafil, a selective PDE5 inhibitor, works by enhancing the nitric oxide–cGMP pathway in the corpus cavernosum of the penis. Sexual arousal triggers the release of nitric oxide (NO) from nerve terminals and endothelial cells. NO stimulates the enzyme guanylyl cyclase, which increases intracellular levels of cyclic guanosine monophosphate (cGMP). cGMP causes smooth muscle relaxation in the corpus cavernosum and penile arteries, allowing increased blood flow into the penis.
Phosphodiesterase type 5 (PDE5) degrades cGMP, terminating the erectile process. Tadalafil inhibits PDE5, prolonging the action of cGMP and thereby sustaining smooth muscle relaxation and penile blood engorgement during sexual arousal. Importantly, without sexual stimulation and the resulting nitric oxide release, tadalafil has no effect.
Tadalafil distinguishes itself from sildenafil and vardenafil by its longer half-life of approximately 17.5 hours, compared to 4–5 hours for the others. This pharmacokinetic profile contributes to its extended duration of action and suitability for daily use in treating PAH or BPH.
The effects of Vidalista 5mg can last up to 36 hours in most individuals. Tadalafil’s long half-life of approximately 17.5 hours supports this extended window of effectiveness. Peak plasma concentrations are usually reached within two hours of administration, although timing may vary based on food intake and metabolism.
Despite the prolonged duration, sexual arousal remains essential for tadalafil to exert its effect. The extended efficacy has earned it the nickname “weekend pill,” enabling more spontaneous sexual activity within the active timeframe. Age, liver function, and concurrent medications may influence the drug’s duration and potency.
The recommended dose of Vidalista 5mg is one tablet per 24-hour period. This dose should be taken approximately 30 to 60 minutes before anticipated sexual activity. Do not exceed one dose in a 24-hour window. A healthcare provider may adjust the dose depending on individual response and tolerability. Overdosing can increase the risk of adverse effects and should be avoided.
For optimal results, take Vidalista 5mg with a full glass of water. It may be taken with or without food, although taking it on an empty stomach may result in a faster onset of action. Avoid heavy or high-fat meals close to the dosing time, as these can delay absorption. Administer the medication about one hour before planned sexual activity to allow adequate time for absorption and action. Always follow the prescribing physician’s guidance for best outcomes.
Vidalista 5mg may cause mild to moderate side effects that generally lessen with continued use. Rare side effects require immediate medical attention.
Common Side Effects
Less Common Side Effects
Rare Side Effects
Seek medical help if you experience severe chest pain, sudden vision or hearing changes, or an erection lasting more than 4 hours. Tadalafil should not be used in patients taking nitrates due to the risk of life-threatening hypotension.
Vidalista 5mg may interact with several drugs and substances that affect blood pressure, hepatic metabolism, and vascular tone. The following table outlines major drug interactions:
Interacting Agent | Effect on Tadalafil | Clinical Recommendation |
---|---|---|
Nitrates (e.g. nitroglycerin) | Increases risk of severe hypotension | Contraindicated. Avoid concurrent use. |
Alpha-blockers (e.g. tamsulosin) | Additive blood pressure-lowering effects | Use with caution and monitor blood pressure. |
Antihypertensives (e.g. amlodipine, enalapril) | Slight BP reduction when combined | Monitor blood pressure; usually safe. |
Alcohol (≥5 units) | Enhances hypotension, dizziness, and tachycardia | Limit or avoid alcohol consumption. |
CYP3A4 Inhibitors (e.g. ketoconazole, ritonavir) | Increases tadalafil plasma levels (AUC and Cmax) | Use with caution; dose adjustment may be necessary. |
CYP3A4 Inducers (e.g. rifampin, phenytoin) | Decreases tadalafil plasma exposure | May reduce efficacy; no dose adjustment needed. |
Antacids (e.g. magnesium hydroxide) | Slows absorption rate, not total exposure | Generally safe. Take separately if possible. |
P-gp substrates (e.g. digoxin) | No significant interaction | No dose adjustment required. |
Vidalista 5mg can be taken with or without food. However, a high-fat meal may delay its onset of action. Consuming alcohol alongside tadalafil may lower blood pressure excessively, leading to dizziness, fainting, or reduced sexual performance. To maximize efficacy and safety, it is advisable to limit or avoid alcohol while using Vidalista 5mg.
Follow the storage instructions listed below to ensure the maximum potency of your drug.
Published on: April 28, 2022
Last Modified on: June 2, 2025
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