Poxet 30 mg

What Is Poxet 30 mg?

Poxet 30 mg is a selective serotonin reuptake inhibitor (SSRI) prescribed for the treatment of Premature Ejaculation (PE) in adult men.

The active ingredient, Dapoxetine Hydrochloride, is a fast-acting SSRI that increases serotonin activity in the central nervous system. This action helps delay ejaculation and improve control over the ejaculation reflex. Initially developed as an antidepressant, Dapoxetine differs from traditional SSRIs in its rapid absorption and elimination, which makes it unsuitable for chronic use in depression but ideal for on-demand treatment of PE. By inhibiting the serotonin transporter (SERT), Dapoxetine prolongs the latency time to ejaculation and enhances the sense of control and sexual satisfaction.

What Is Poxet 30 mg Used For?

Poxet 30 mg is used to manage Premature Ejaculation (PE) in men aged 18 to 64 years. Premature Ejaculation is defined as ejaculation that occurs with minimal sexual stimulation before, during, or shortly after penetration, causing distress or interpersonal difficulty. Poxet 30 mg does not cure PE but helps delay ejaculation, thereby improving sexual satisfaction and reducing personal distress.

According to randomised, placebo-controlled trials, Dapoxetine significantly improves intravaginal ejaculation latency time (IELT) and enhances the feeling of ejaculatory control. While 60 mg doses offer better outcomes for lifelong PE, 30 mg is effective for most patients. Unlike traditional SSRIs used off-label, Dapoxetine is faster acting and cleared more quickly, reducing the risks of adverse effects, tolerance, or accumulation.

How Long Does It Take For Poxet 30 mg To Start Working?

Poxet 30 mg starts working within 1 to 3 hours after oral administration. Dapoxetine is absorbed rapidly in the gastrointestinal tract, with its maximum plasma concentration (Cmax) reached in about 1.01 hours for the 30 mg dose. Its fast onset of action is attributed to its unique pharmacokinetic profile, which enables rapid absorption and early peak concentration. Once absorbed, Dapoxetine binds extensively (over 99%) to plasma proteins and inhibits the serotonin transporter (SERT) in the central nervous system.

By blocking SERT, Dapoxetine increases serotonin levels at synaptic junctions, especially in regions of the brain involved in the ejaculatory reflex. This modulation of serotonergic pathways, particularly within the medial preoptic area, paraventricular nucleus, and lateral paragigantocellular nucleus (LPGi), leads to inhibition of the ejaculatory expulsion reflex. The result is an increase in pudendal motor neuron reflex discharge latency, which delays ejaculation. While absorption is generally consistent, onset may vary depending on individual metabolic rates, gastrointestinal conditions, and the presence of food in the stomach.

How Long Do The Effects Of Poxet 30 mg Last?

The effects of Poxet 30 mg typically last for about 1 to 3 hours after administration. Poxet 30 mg contains dapoxetine, a short-acting selective serotonin reuptake inhibitor (SSRI) developed for the treatment of premature ejaculation. Dapoxetine reaches peak plasma concentration in approximately 1 hour after oral intake and has an initial half-life of 1.4 hours, with a terminal half-life of 18.7 hours. Despite the longer terminal half-life, the therapeutic effect, a delay in ejaculation, occurs within 1 to 3 hours and is closely tied to the initial plasma peak.

The drug is rapidly absorbed and eliminated, which supports its on-demand use rather than daily dosing. Dapoxetine does not accumulate in the body with repeated use, meaning the effect does not extend with multiple doses.

What Is The Recommended Dosage Of Poxet 30 mg?

The recommended starting dose is 30 mg taken 1 to 3 hours before anticipated sexual activity. A physician may increase the dose to 60 mg if the lower dose does not provide adequate effect and is well tolerated. Patients should not take more than one tablet in 24 hours. Dapoxetine is prescribed only for men diagnosed with PE and is not intended for daily use or treatment of erectile dysfunction.

What Are The Side Effects Of Poxet 30 mg Tablet?

Poxet 30 mg may cause mild to moderate side effects in some users.

Common side effects:

• Headache
• Dizziness
• Nausea
• Dry mouth
• Insomnia

Serious but rare side effects:

• Syncope (fainting)
• Seizures
• Changes in mood or behavior
• Blurred vision

Seek medical help immediately if you experience prolonged dizziness, fainting, or signs of serotonin syndrome (e.g., confusion, hallucinations, or muscle rigidity).

What Are The Drug Interactions Of Poxet 30 mg?

Poxet 30 mg may interact with other medications, especially those affecting serotonin levels or liver enzymes.

Can I Take Poxet 30 mg With Food Or Alcohol?

Poxet 30 mg can be taken with or without food, but alcohol should be used cautiously. Dapoxetine’s pharmacokinetics are not significantly affected by food intake. However, alcohol may exacerbate side effects such as dizziness, drowsiness, and fainting. Combining alcohol with Dapoxetine may also impair judgment and increase the risk of accidental injury.

How Should Poxet 30 mg Be Stored?

Follow the storage instructions listed below to ensure the maximum potency of your drug.

• Keep in a cool, dry place below 30°C (86°F)
• Store away from direct sunlight
• Keep out of reach of children and pets
• Do not store in bathroom cabinets (due to humidity)
• Use only until the expiry date
• Keep in the original blister packaging

Written & Reviewed By

Dr. William Henderson

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